MMD2

Across TCGA cell cohorts, MMD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 352 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MMD2-associated GO terms across cancer lineages are RNA surveillance, Positive regulation of myeloid leukocyte differentiation, and RNA polymerase II transcription initiation surveillance. Each is linked with MMD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MMD2-to-partner and partner-to-MMD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA surveillance grouped by MMD2-low versus MMD2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MMD2→partner) and Y-score (partner→MMD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RNA surveillance →	+0.054	+0.007	<.001	.007	3	4
LUNG_SCLC	Positive regulation of myeloid leukocyte differentiation →	-0.054	-0.525	.005	.005	3	4
PANCREAS	RNA polymerase II transcription initiation surveillance →	+0.057	+0.007	.002	.007	3	3
PANCREAS	Amino acid neurotransmitter reuptake →	+0.407	+0.007	.001	.007	3	3
PANCREAS	Gamma-aminobutyric acid reuptake →	+0.407	+0.007	.001	.007	3	3
PANCREAS	DNA-templated transcription initiation →	+0.046	+0.007	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 352 associations by consensus.

RNA surveillance by MMD2 expression — PANCREAS

Explore this box plot interactively →