MMD2

Across TCGA cell cohorts, MMD2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MMD2-associated genes across cancer lineages are MBD3L5, OR5V1, and TEX26. Each is linked with MMD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMD2-to-partner and partner-to-MMD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L5 grouped by MMD2-low versus MMD2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMD2→partner) and Y-score (partner→MMD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MBD3L5 →	+0.032	+5.415	<.001	.004	3	1
SKIN	OR5V1 →	+0.016	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	TEX26 →	+0.025	+5.228	<.001	.005	3	1
STOMACH	VN1R3 →	+0.026	+5.285	<.001	.003	3	1
STOMACH	FAM240A →	+0.070	+5.285	<.001	.003	3	1
LARGE_INTESTINE	ELOA3DP →	+0.029	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MBD3L5 by MMD2 expression — SKIN

Explore this box plot interactively →