MMADHC-DT

Across TCGA pan-cancer cohorts, MMADHC-DT RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MMADHC-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MMADHC-DT RNA is repressed in tumor relative to normal tissue. In most cancer types MMADHC-DT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and HNSC are the cancer types where MMADHC-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MMADHC-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.066	<.001	11	view →
THCA	All	II,III,IV	−0.322	<.001	10	view →
HNSC	All	III,IV	+0.312	.001	10	view →
LIHC	Female	II,III,IV	−0.515	<.001	9	view →
LUAD	Female	III,IV	−0.492	.001	6	view →
BRCA	All	III,IV	−0.385	<.001	6	view →
BLCA	All	All	−0.232	.008	5	view →
KIRC	All	All	+0.234	<.001	4	view →
CHOL	All	All	−0.544	.003	2	view →
READ	Female	All	−0.396	.024	2	view →
LUSC	Female	All	−0.296	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MMADHC-DT–KICH

Open the KICH breakdown →