MMAA

Across TCGA patient cohorts, MMAA mutation is significantly associated with the RNA expression of many other genes, with 1,203 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMAA-associated genes across cancer lineages are TEKT4P3, MIR8064, and TYMSOS. Each is linked with MMAA in more than 1 cancer types. Because this analysis shows association rather than direction, both MMAA-to-partner and partner-to-MMAA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEKT4P3 grouped by MMAA-low versus MMAA-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMAA→partner) and Y-score (partner→MMAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TEKT4P3 →	+0.290	+4.376	<.001	.002	3	2
BLCA	MIR8064 →	+0.416	+4.004	.006	.006	3	2
UCEC	TYMSOS →	+0.722	+3.595	<.001	.001	3	2
COAD	PIGPP3 →	+0.416	+5.017	<.001	.009	3	2
COAD	RPS12P15 →	+0.275	+5.693	<.001	.003	3	2
CESC	SRIP3 →	+0.224	+4.455	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,203 associations by consensus.

TEKT4P3 by MMAA expression — BLCA

Explore this box plot interactively →