MLXIPL

Across TCGA patient cohorts, MLXIPL protein abundance is significantly associated with the protein abundance of many other proteins, with 1,955 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible MLXIPL-associated proteins across cancer lineages are ARHGEF6, ACE2, and ARID3B_S89. Each is linked with MLXIPL in more than 1 cancer types. Because this analysis shows association rather than direction, both MLXIPL-to-partner and partner-to-MLXIPL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MLXIPL versus ARHGEF6 in CCRCC, with a Pearson correlation of -0.38.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MLXIPL→partner) and Y-score (partner→MLXIPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ARHGEF6 →	-0.241	-0.340	.001	.001	3	1
CCRCC	ACE2 →	+0.651	+0.503	.001	.001	3	1
CCRCC	ARID3B_S89 →	-0.765	-0.561	<.001	.001	3	1
CCRCC	ARIH1 →	-0.279	-0.418	<.001	.002	3	1
CCRCC	ARIH2 →	-0.196	-0.349	<.001	.001	3	1
CCRCC	ARL6_S44 →	+0.570	+0.451	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,955 associations by consensus.

MLXIPL vs ARHGEF6 — CCRCC

Explore this scatter interactively →