MLXIPL

Across TCGA patient cohorts, MLXIPL mutation is significantly associated with the RNA expression of many other genes, with 2,238 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLXIPL-associated genes across cancer lineages are EIF2B2, MIR3925, and SLC39A14. Each is linked with MLXIPL in more than 3 cancer types. Because this analysis shows association rather than direction, both MLXIPL-to-partner and partner-to-MLXIPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF2B2 grouped by MLXIPL-low versus MLXIPL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLXIPL→partner) and Y-score (partner→MLXIPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EIF2B2 →	+0.355	+2.260	.005	.005	3	4
CESC	MIR3925 →	+0.798	+6.144	<.001	.001	3	3
SKCM	SLC39A14 →	+0.680	+2.398	.001	<.001	3	3
SKCM	ALDOA →	+0.376	+2.070	.008	.001	3	3
UCEC	MTFP1 →	+0.608	+3.459	.004	.005	2	4
LUSC	MIR485 →	+0.117	+4.005	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,238 associations by consensus.

EIF2B2 by MLXIPL expression — SKCM

Explore this box plot interactively →