MLXIPL

Across TCGA patient cohorts, MLXIPL mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLXIPL-associated genes across cancer lineages are p70-S6K_pT389, Cyclin-E2, and 4E-BP1. Each is linked with MLXIPL in more than 2 cancer types. Because this analysis shows association rather than direction, both MLXIPL-to-partner and partner-to-MLXIPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by MLXIPL-low versus MLXIPL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLXIPL→partner) and Y-score (partner→MLXIPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p70-S6K_pT389 →	-0.182	-2.415	.005	.003	3	3
STAD	Cyclin-E2 →	+0.173	+2.828	.019	.033	3	2
UCEC	4E-BP1 →	+0.412	+2.837	.002	.035	2	3
SKCM	IGFBP2 →	-0.450	-2.584	.028	.010	3	2
UCEC	p70-S6K →	+0.272	+3.486	.004	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.874	+3.189	.003	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

p70-S6K_pT389 by MLXIPL expression — SKCM

Explore this box plot interactively →