MLXIP

Across TCGA pan-cancer cohorts, MLXIP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MLXIP data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MLXIP mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MLXIP expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where MLXIP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.869	0.551	<.001	46	view →
CCRCC	DFS	Tertile	All	0.618	0.900	.002	28	view →
LSCC	DFS	Tertile	III,IV	0.500	1.000	.005	22	view →
PDAC	OS	Quartile	III,IV	0.965	0.302	.027	7	view →
UCEC	DFS	Median	All	0.918	0.788	.048	2	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.835	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MLXIP–HNSC (OS)

Open the HNSC breakdown →