MLXIP

Across TCGA pan-cancer cohorts, MLXIP RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MLXIP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MLXIP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MLXIP is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

HNSC, THCA, and BLCA are the cancer types where MLXIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MLXIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.083	<.001	11	view →
THCA	All	II,III,IV	−0.772	<.001	10	view →
BLCA	Male	III,IV	−1.832	<.001	8	view →
LIHC	Male	II,III,IV	+1.231	<.001	8	view →
COAD	All	III,IV	−0.881	<.001	8	view →
BRCA	All	III,IV	−0.589	<.001	6	view →
KIRP	All	All	+0.473	.004	6	view →
CHOL	All	All	+2.045	<.001	5	view →
KIRC	All	All	+0.239	.013	3	view →
UCEC	All	All	−0.707	.002	2	view →
KICH	All	All	−0.614	.003	2	view →
PAAD	All	All	−0.497	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MLXIP–HNSC

Open the HNSC breakdown →