MLXIP

Across TCGA cell cohorts, MLXIP RNA expression is significantly associated with the go_rna of many other GO terms, with 5,127 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MLXIP-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Endosomal transport, and Peptidyl-serine phosphorylation. Each is linked with MLXIP in more than 15 cancer types. Because this analysis shows association rather than direction, both MLXIP-to-partner and partner-to-MLXIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by MLXIP-low versus MLXIP-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MLXIP→partner) and Y-score (partner→MLXIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.179	+0.843	.001	<.001	3	16
CNS	Endosomal transport →	+0.059	+0.988	<.001	<.001	3	14
BONE	Peptidyl-serine phosphorylation →	+0.080	+0.809	.002	.001	3	14
SOFT_TISSUE	Peptidyl-serine modification →	+0.065	+0.936	<.001	<.001	3	14
URINARY_TRACT	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.207	+0.926	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.101	-0.605	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,127 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by MLXIP expression — URINARY_TRACT

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