MLXIP

Across TCGA cell cohorts, MLXIP mutation is significantly associated with the RNA expression of many other genes, with 269 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MLXIP-associated genes across cancer lineages are SERPINA7, C2orf73, and GID4. Each is linked with MLXIP in more than 1 cancer types. Because this analysis shows association rather than direction, both MLXIP-to-partner and partner-to-MLXIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA7 grouped by MLXIP-low versus MLXIP-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLXIP→partner) and Y-score (partner→MLXIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	2
LARGE_INTESTINE	C2orf73 →	+0.062	+3.443	.002	.009	3	2
BLOOD_Leukemia	GID4 →	+1.013	+3.120	<.001	.009	3	2
BLOOD_Leukemia	PRR30 →	+0.015	+3.362	<.001	.001	3	2
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
CNS	LCE2C →	+0.038	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 269 associations by consensus.

SERPINA7 by MLXIP expression — BLOOD_Myeloma

Explore this box plot interactively →