MLPH

Across TCGA cell cohorts, MLPH mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MLPH-associated genes across cancer lineages are OR6B3, TCP11X1, and BVES. Each is linked with MLPH in more than 1 cancer types. Because this analysis shows association rather than direction, both MLPH-to-partner and partner-to-MLPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6B3 grouped by MLPH-low versus MLPH-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLPH→partner) and Y-score (partner→MLPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR6B3 →	+0.024	+4.121	.001	.006	3	1
KIDNEY	TCP11X1 →	+0.027	+4.491	.001	.002	3	1
LARGE_INTESTINE	BVES →	+0.525	+3.355	<.001	.007	3	1
LARGE_INTESTINE	OR14K1 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	CENPVL3 →	+0.249	+3.242	<.001	.003	3	1
BLOOD_Leukemia	DEFB125 →	+0.044	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR6B3 by MLPH expression — KIDNEY

Explore this box plot interactively →