MLNR

Across TCGA patient cohorts, MLNR mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLNR-associated genes across cancer lineages are Fibronectin, MSH2, and p62 Lck ligand. Each is linked with MLNR in more than 1 cancer types. Because this analysis shows association rather than direction, both MLNR-to-partner and partner-to-MLNR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by MLNR-low versus MLNR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLNR→partner) and Y-score (partner→MLNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.355	-2.990	.026	.036	3	1
UCEC	MSH2 →	-0.317	-3.143	.004	.018	3	1
UCEC	p62 Lck ligand →	+0.404	+2.459	.010	.020	3	1
UCEC	PI3K-p110-a →	-0.234	-2.459	.006	.020	3	1
UCEC	BRCA2 →	-0.168	-3.577	.006	.002	3	1
UCEC	CD49b →	-0.313	-2.986	.022	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Fibronectin by MLNR expression — UCEC

Explore this box plot interactively →