MLN

Across TCGA patient cohorts, MLN RNA expression is significantly associated with the go_rna of many other GO terms, with 6,953 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible MLN-associated GO terms across cancer lineages are Regulation of DNA-templated transcription elongation, Regulation of post-translational protein modification, and Epigenetic regulation of gene expression. Each is linked with MLN in more than 20 cancer types. Because this analysis shows association rather than direction, both MLN-to-partner and partner-to-MLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated transcription elongation grouped by MLN-low versus MLN-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MLN→partner) and Y-score (partner→MLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of DNA-templated transcription elongation →	+0.058	+0.636	<.001	<.001	3	21
STAD	Regulation of post-translational protein modification →	+0.055	+0.702	<.001	<.001	3	20
STAD	Epigenetic regulation of gene expression →	+0.053	+0.572	<.001	<.001	3	20
STAD	Mitochondrial gene expression →	+0.054	+0.505	<.001	<.001	3	19
ESCA	Positive regulation of DNA repair →	+0.049	+0.203	<.001	<.001	2	20
STAD	Negative regulation of gene expression, epigenetic →	+0.052	+0.579	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,953 associations by consensus.

Regulation of DNA-templated transcription elongation by MLN expression — STAD

Explore this box plot interactively →