MLN

Across TCGA cell cohorts, MLN RNA expression is significantly associated with the mutation status of many other genes, with 99 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible MLN-associated genes across cancer lineages are FBN1, SMG9, and RAPGEF2. Each is linked with MLN in more than 1 cancer types. Because this analysis shows association rather than direction, both MLN-to-partner and partner-to-MLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBN1 grouped by MLN-low versus MLN-high in LUNG_NSCLC_LUAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLN→partner) and Y-score (partner→MLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FBN1 →	+2.528	+0.028	.001	<.001	3	2
LUNG_NSCLC_LUAD	SMG9 →	+5.228	+0.087	.005	<.001	3	1
LUNG_NSCLC_LUAD	RAPGEF2 →	+5.228	+0.087	.005	<.001	3	1
LUNG_NSCLC_LUAD	ADGRE5 →	+5.228	+0.083	.005	<.001	3	1
LUNG_NSCLC_LUAD	PALLD →	+4.813	+0.063	<.001	<.001	3	1
LUNG_NSCLC_LUAD	TRPC4 →	+2.813	+0.027	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

FBN1 by MLN expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →