MLLT1

Across TCGA patient cohorts, MLLT1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLLT1-associated genes across cancer lineages are ERK2, Shc_pY317, and ATM. Each is linked with MLLT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLLT1-to-partner and partner-to-MLLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MLLT1-low versus MLLT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLLT1→partner) and Y-score (partner→MLLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.175	+2.169	.006	.003	3	2
UCEC	Shc_pY317 →	-0.123	-1.321	.015	.029	3	2
UCEC	ATM →	-0.547	-2.201	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.634	+2.019	.001	.005	3	2
UCEC	eEF2 →	+0.335	+2.115	.005	.017	3	1
UCEC	FOXO3a_pS318_S321 →	-0.083	-1.321	.046	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ERK2 by MLLT1 expression — UCEC

Explore this box plot interactively →