MLKL

Across TCGA patient cohorts, MLKL RNA expression is significantly associated with the protein abundance of many other proteins, with 22,103 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MLKL-associated proteins across cancer lineages are CRLF3, DEF6, and GBP4. Each is linked with MLKL in more than 8 cancer types. Because this analysis shows association rather than direction, both MLKL-to-partner and partner-to-MLKL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MLKL versus CRLF3 in BRCA, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MLKL→partner) and Y-score (partner→MLKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CRLF3 →	+0.443	+0.586	<.001	.001	3	9
GBM	DEF6 →	+0.717	+0.804	<.001	<.001	3	9
UCEC	GBP4 →	+0.724	+0.764	<.001	.002	3	9
GBM	NADK →	+0.406	+0.597	<.001	<.001	3	9
HNSC	IFI35 →	+0.572	+0.536	<.001	<.001	3	9
GBM	LCP2 →	+0.629	+0.855	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,103 associations by consensus.

MLKL vs CRLF3 — BRCA

Explore this scatter interactively →