MLKL

Across TCGA pan-cancer cohorts, MLKL RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MLKL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MLKL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MLKL is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where MLKL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MLKL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.690	<.001	11	view →
COAD	All	III,IV	+1.043	<.001	11	view →
KIRP	All	IV	+1.945	<.001	9	view →
STAD	All	III,IV	+1.196	<.001	9	view →
KICH	Female	All	−1.110	<.001	8	view →
LIHC	All	II,III,IV	+0.604	<.001	7	view →
READ	All	II,III,IV	+1.255	.003	6	view →
LUSC	Female	All	−1.133	<.001	6	view →
HNSC	All	All	+0.401	.005	6	view →
ESCA	All	All	+0.978	.005	4	view →
BRCA	Female	II,III,IV	−0.207	.009	4	view →
CHOL	All	All	+2.301	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MLKL–KIRC

Open the KIRC breakdown →