MLKL

Across TCGA patient cohorts, MLKL protein abundance is significantly associated with the RNA expression of many other genes, with 19,941 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MLKL-associated genes across cancer lineages are ZBP1, ITGB7, and NLRC5. Each is linked with MLKL in more than 7 cancer types. Because this analysis shows association rather than direction, both MLKL-to-partner and partner-to-MLKL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MLKL versus ZBP1 in BRCA, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLKL→partner) and Y-score (partner→MLKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZBP1 →	+1.210	+0.564	<.001	<.001	3	8
OV	ITGB7 →	+0.729	+0.558	<.001	.001	3	8
BRCA	NLRC5 →	+0.841	+0.396	<.001	<.001	3	8
HNSC	GNGT2 →	+0.641	+0.351	<.001	<.001	3	8
HNSC	GLRX →	+0.739	+0.477	<.001	<.001	3	8
BRCA	CCL5 →	+1.517	+0.447	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,941 associations by consensus.

MLKL vs ZBP1 — BRCA

Explore this scatter interactively →