MLKL

Across TCGA patient cohorts, MLKL mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLKL-associated genes across cancer lineages are INPP4B, Ku80, and Myosin-IIa_pS1943. Each is linked with MLKL in more than 1 cancer types. Because this analysis shows association rather than direction, both MLKL-to-partner and partner-to-MLKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by MLKL-low versus MLKL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLKL→partner) and Y-score (partner→MLKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.426	-3.459	.004	.005	3	1
UCEC	Ku80 →	+0.228	+1.887	.038	.031	3	1
UCEC	Myosin-IIa_pS1943 →	+0.196	+1.887	.041	.031	3	1
UCEC	Notch1 →	+0.182	+2.820	.005	.035	3	1
UCEC	Tuberin →	+0.304	+2.584	.015	.011	3	1
UCEC	CD49b →	-0.351	-3.156	.008	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

INPP4B by MLKL expression — UCEC

Explore this box plot interactively →