MLKL

Across TCGA cell cohorts, MLKL RNA expression is significantly associated with the go_rna of many other GO terms, with 5,006 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MLKL-associated GO terms across cancer lineages are Defense response to virus, Necroptotic signaling pathway, and Cytoplasmic pattern recognition receptor signaling pathway. Each is linked with MLKL in more than 11 cancer types. Because this analysis shows association rather than direction, both MLKL-to-partner and partner-to-MLKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Defense response to virus grouped by MLKL-low versus MLKL-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MLKL→partner) and Y-score (partner→MLKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Defense response to virus →	+0.083	+1.462	<.001	<.001	3	12
CNS	Necroptotic signaling pathway →	+0.203	+0.906	.006	<.001	3	11
BLOOD_Myeloma	Cytoplasmic pattern recognition receptor signaling pathway →	+0.070	+1.858	<.001	.001	3	11
LUNG_NSCLC_LUAD	Death-inducing signaling complex assembly →	+0.169	+1.416	<.001	<.001	3	11
SOFT_TISSUE	Positive regulation of innate immune response →	+0.037	+1.276	<.001	.003	3	10
LIVER	Negative regulation of IP-10 production →	+1.764	+1.843	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,006 associations by consensus.

Defense response to virus by MLKL expression — BREAST

Explore this box plot interactively →