MLKL

Across TCGA cell cohorts, MLKL mutation is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MLKL-associated genes across cancer lineages are ZIC5, DIRAS2, and TACR3. Each is linked with MLKL in more than 1 cancer types. Because this analysis shows association rather than direction, both MLKL-to-partner and partner-to-MLKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC5 grouped by MLKL-low versus MLKL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLKL→partner) and Y-score (partner→MLKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZIC5 →	+1.279	+3.212	<.001	.006	3	2
BLOOD_Leukemia	DIRAS2 →	+0.093	+4.502	<.001	.001	3	1
BLOOD_Leukemia	TACR3 →	+0.028	+3.475	<.001	.006	3	1
BLOOD_Leukemia	PRND →	+0.007	+3.289	<.001	.009	3	1
BLOOD_Leukemia	TEX43 →	+0.070	+3.969	<.001	.009	3	1
BLOOD_Leukemia	CCT8L2 →	+0.012	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

ZIC5 by MLKL expression — LARGE_INTESTINE

Explore this box plot interactively →