MLIP-IT1

Across TCGA pan-cancer cohorts, MLIP-IT1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MLIP-IT1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher MLIP-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MLIP-IT1 expression acts as an unfavorable survival marker, although some lineages such as MESO and LIHC show a favorable association.

BRCA, UCS, and STAD are the cancer types where MLIP-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	II,III,IV	0.934	0.969	<.001	66	view →
UCS	OS	Tertile	II,III,IV	0.226	0.666	.001	66	view →
STAD	OS	Quartile	II,III,IV	0.336	0.648	.002	27	view →
MESO	OS	Quartile	All	0.454	0.251	.019	24	view →
THCA	OS	Median	II,III,IV	0.323	1.000	.001	24	view →
LIHC	OS	Tertile	All	0.748	0.578	.010	19	view →
LGG	DFS	Quartile	All	0.236	0.430	.003	19	view →
COAD	DFS	Tertile	IV	0.313	0.522	.039	18	view →
CHOL	OS	Tertile	II,III,IV	0.080	0.740	.026	18	view →
SKCM	DFS	Tertile	III,IV	0.118	0.364	.013	17	view →
READ	OS	Tertile	III,IV	0.665	0.949	.014	15	view →
LUAD	OS	Quartile	II,III,IV	0.823	0.671	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MLIP-IT1–BRCA (OS)

Open the BRCA breakdown →