MLIP-IT1

Across TCGA pan-cancer cohorts, MLIP-IT1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MLIP-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MLIP-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types MLIP-IT1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, LUSC, and BRCA are the cancer types where MLIP-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MLIP-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.740	<.001	11	view →
LUSC	Male	All	+0.550	<.001	6	view →
BRCA	All	III,IV	−0.395	<.001	6	view →
KIRC	Male	All	+0.389	<.001	5	view →
CHOL	All	II,III,IV	−0.329	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MLIP-IT1–THCA

Open the THCA breakdown →