MLC1

Across TCGA cell cohorts, MLC1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MLC1-associated genes across cancer lineages are ODF4, CNGA2, and NPSR1. Each is linked with MLC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLC1-to-partner and partner-to-MLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ODF4 grouped by MLC1-low versus MLC1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLC1→partner) and Y-score (partner→MLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ODF4 →	+0.035	+5.196	<.001	.005	3	1
BLOOD_Leukemia	CNGA2 →	+0.074	+4.539	<.001	.007	3	1
BLOOD_Leukemia	NPSR1 →	+0.028	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CCT8L2 →	+0.011	+4.874	<.001	.002	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.092	+4.539	<.001	.007	3	1
BLOOD_Leukemia	SERPINB11 →	+0.028	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ODF4 by MLC1 expression — OVARY

Explore this box plot interactively →