makorin ring finger protein 7, pseudogeneGenealiases: MKRNP3 · ZNF127L5 · dJ981L23.2
Q-omics provides the consensus-scored MKRN7P profile across patient tissues and cancer cell-line models. MKRN7P expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, MKRN7P is differentially expressed in 9, with the highest sampling consensus in UCEC. Additionally, MKRN7P RNA expression shows 14,977 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight UVM, UCEC, and THYM as cancer lineages where MKRN7P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MKRN7P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MKRN7P survival associations across molecular data types. MKRN7P RNA expression shows survival associations in the most cancer types (19), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MKRN7P RNA expression–survival associations across cancer types. High MKRN7P expression shows unfavorable associations in LGG, UCEC and COAD, but favorable associations in UVM, KIRP and BLCA. The UVM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for MKRN7P RNA expression.
This table summarizes MKRN7P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for MKRN7P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MKRN7P shows lower tumor expression in UCEC, BRCA, KICH, THCA, KIRC and LUSC. The UCEC box plot shows higher MKRN7P RNA expression in normal versus tumor tissue (log2 FC = −0.946, t-test p < 0.001).
This table shows molecular features associated with MKRN7P in patient tissues and cancer cell lines. In patient samples, MKRN7P shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, MKRN7P RNA and mutation anchors are most strongly linked to RNA-expression features, especially in NCI60_ALL.
