makorin ring finger protein 5, pseudogeneGenealiases: MKRNP1 · ZNF-Xq · ZNF127L2
Q-omics provides the consensus-scored MKRN5P profile across patient tissues and cancer cell-line models. MKRN5P expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, MKRN5P is differentially expressed in 5, with the highest sampling consensus in COAD. Additionally, MKRN5P RNA expression shows 16,885 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KICH, COAD, and THYM as cancer lineages where MKRN5P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MKRN5P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MKRN5P survival associations across molecular data types. MKRN5P RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MKRN5P RNA expression–survival associations across cancer types. High MKRN5P expression shows unfavorable associations in KICH, KIRC and LUSC, but favorable associations in HNSC, LIHC and LAML. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify KICH as the clearest survival context for MKRN5P RNA expression.
This table summarizes MKRN5P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for MKRN5P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MKRN5P shows lower tumor expression in LUSC and higher tumor expression in COAD, HNSC, THCA and LIHC. The COAD box plot shows higher MKRN5P RNA expression in tumor versus normal tissue (log2 FC = +0.121, t-test p < 0.001).
This table shows molecular features associated with MKRN5P in patient tissues and cancer cell lines. In patient samples, MKRN5P shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
