makorin ring finger protein 4, pseudogeneGenealiases: MKRN4 · MKRNP5 · RNF64 · ZNF-Xp · ZNF127-Xp · ZNF127L1
Q-omics provides the consensus-scored MKRN4P profile across patient tissues and cancer cell-line models. MKRN4P expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in READ. Among the 18 cancer types available for tumor–normal comparison, MKRN4P is differentially expressed in 6, with the highest sampling consensus in HNSC. Additionally, MKRN4P RNA expression shows 10,688 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight READ, HNSC, and THYM as cancer lineages where MKRN4P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MKRN4P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MKRN4P survival associations across molecular data types. MKRN4P RNA expression shows survival associations in the most cancer types (25). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MKRN4P RNA expression–survival associations across cancer types. High MKRN4P expression shows unfavorable associations in OV, KIRP and BRCA, but favorable associations in READ, ACC and BLCA. The READ Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify READ as the clearest survival context for MKRN4P RNA expression.
This table summarizes MKRN4P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for MKRN4P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MKRN4P shows lower tumor expression in LUSC and LUAD and higher tumor expression in HNSC, BRCA, LIHC and THCA. The HNSC box plot shows higher MKRN4P RNA expression in tumor versus normal tissue (log2 FC = +0.376, t-test p < 0.001).
This table shows molecular features associated with MKRN4P in patient tissues and cancer cell lines. In patient samples, MKRN4P shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
