MKRN3

Across TCGA cell cohorts, MKRN3 mutation is significantly associated with the RNA expression of many other genes, with 351 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MKRN3-associated genes across cancer lineages are FBXO40, OR11H6, and SLC13A2. Each is linked with MKRN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MKRN3-to-partner and partner-to-MKRN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO40 grouped by MKRN3-low versus MKRN3-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKRN3→partner) and Y-score (partner→MKRN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FBXO40 →	+0.007	+3.977	<.001	.006	3	1
LIVER	OR11H6 →	+0.033	+3.977	<.001	.006	3	1
BLOOD_Myeloma	SLC13A2 →	+0.013	+4.807	<.001	.006	3	1
CNS	HELT →	+0.055	+5.321	<.001	.005	3	1
SKIN	PAK5 →	+0.059	+3.658	.001	.005	3	1
SKIN	ZNF835 →	+0.187	+4.291	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 351 associations by consensus.

FBXO40 by MKRN3 expression — LIVER

Explore this box plot interactively →