MKNK1-AS1

Across TCGA pan-cancer cohorts, MKNK1-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MKNK1-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MKNK1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MKNK1-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, LGG, and PRAD are the cancer types where MKNK1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.870	0.712	<.001	60	view →
LGG	DFS	Median	All	0.674	0.801	<.001	41	view →
PRAD	DFS	Median	All	0.832	0.931	<.001	34	view →
UVM	DFS	Quartile	III,IV	0.180	0.830	.003	33	view →
MESO	DFS	Tertile	III,IV	0.255	0.437	.002	33	view →
SKCM	OS	Median	II,III,IV	0.808	0.662	.002	30	view →
ESCA	OS	Median	III,IV	0.625	0.321	.005	20	view →
BRCA	OS	Quartile	III,IV	0.902	0.738	.008	18	view →
ACC	OS	Tertile	IV	0.219	0.850	.024	18	view →
THCA	DFS	Median	IV	0.466	0.781	.005	9	view →
KIRC	DFS	Median	IV	0.267	0.450	.033	6	view →
OV	OS	Quartile	III,IV	0.334	0.440	.027	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MKNK1-AS1–HNSC (OS)

Open the HNSC breakdown →