MKNK1-AS1

Across TCGA pan-cancer cohorts, MKNK1-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MKNK1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MKNK1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MKNK1-AS1 is over-expressed in tumor, although a few such as KIRP and BRCA show the opposite, repressed pattern.

HNSC, KIRP, and BRCA are the cancer types where MKNK1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MKNK1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.092	.002	8	view →
KIRP	All	All	−0.124	.003	5	view →
BRCA	All	III,IV	−0.187	.002	4	view →
LIHC	All	All	+0.054	.002	3	view →
CHOL	All	All	+0.374	<.001	2	view →
KICH	All	All	−0.103	.004	2	view →
STAD	Male	II,III,IV	+0.219	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

MKNK1-AS1–HNSC

Open the HNSC breakdown →