MKLN1-AS

Across TCGA pan-cancer cohorts, MKLN1-AS RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MKLN1-AS data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MKLN1-AS RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MKLN1-AS expression acts as an unfavorable survival marker, although some lineages such as KIRC and STAD show a favorable association.

KIRC, LIHC, and CESC are the cancer types where MKLN1-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.714	0.541	<.001	112	view →
LIHC	OS	Median	All	0.592	0.776	<.001	93	view →
CESC	DFS	Quartile	All	0.628	0.864	<.001	64	view →
ACC	OS	Quartile	III,IV	0.495	0.901	.001	38	view →
STAD	OS	Tertile	III,IV	0.618	0.355	.006	32	view →
KIRP	DFS	Tertile	III,IV	0.098	0.618	.005	30	view →
HNSC	DFS	Quartile	III,IV	0.574	0.758	.007	23	view →
MESO	DFS	Median	III,IV	0.207	0.576	.004	21	view →
READ	OS	Tertile	All	0.970	0.732	.005	19	view →
COAD	OS	Tertile	III,IV	0.939	0.652	.005	17	view →
PAAD	DFS	Quartile	All	0.231	0.561	.007	17	view →
BRCA	DFS	Median	III,IV	0.919	0.834	.011	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MKLN1-AS–KIRC (DFS)

Open the KIRC breakdown →