MKLN1-AS

Across TCGA pan-cancer cohorts, MKLN1-AS RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MKLN1-AS’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MKLN1-AS RNA is repressed in tumor relative to normal tissue. In most cancer types MKLN1-AS is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRC are the cancer types where MKLN1-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MKLN1-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−1.193	<.001	11	view →
KICH	Female	II,III,IV	−2.130	<.001	10	view →
KIRC	Female	All	−0.767	<.001	10	view →
LUAD	Male	II,III,IV	+0.928	<.001	9	view →
LIHC	Male	All	+0.778	<.001	9	view →
CHOL	All	All	+1.645	<.001	5	view →
COAD	Male	II,III,IV	+0.517	<.001	4	view →
UCEC	All	All	−0.502	<.001	4	view →
READ	All	All	+0.663	.015	2	view →
HNSC	Female	III,IV	+0.594	.044	2	view →
PRAD	All	All	+0.259	.010	2	view →
LUSC	All	II,III,IV	−0.204	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MKLN1-AS–THCA

Open the THCA breakdown →