MKKS

Across TCGA pan-cancer cohorts, MKKS Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MKKS data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MKKS Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MKKS expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, UCEC, and LUSC are the cancer types where MKKS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.248	0.871	<.001	30	view →
UCEC	DFS	Median	All	1.000	0.620	.012	30	view →
LUSC	OS	Median	All	0.176	0.724	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MKKS–KIRP (DFS)

Open the KIRP breakdown →