MKKS

Across TCGA patient cohorts, MKKS mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKKS-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and IRS1. Each is linked with MKKS in more than 1 cancer types. Because this analysis shows association rather than direction, both MKKS-to-partner and partner-to-MKKS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by MKKS-low versus MKKS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKKS→partner) and Y-score (partner→MKKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.205	-3.700	<.001	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.141	-1.690	.006	.042	3	1
UCEC	IRS1 →	+0.170	+1.807	.047	.027	3	1
UCEC	JNK2 →	+0.233	+2.196	.004	.032	3	1
UCEC	Ku80 →	+0.261	+1.820	.007	.016	3	1
UCEC	mTOR_pS2448 →	-0.153	-2.321	.013	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

A-Raf_pS299 by MKKS expression — UCEC

Explore this box plot interactively →