MKKS

Across TCGA cell cohorts, MKKS RNA expression is significantly associated with the go_rna of many other GO terms, with 2,354 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MKKS-associated GO terms across cancer lineages are Negative regulation of appetite by leptin-mediated signaling pathway, Detection of mechanical stimulus involved in sensory perception of sound, and Convergent extension. Each is linked with MKKS in more than 17 cancer types. Because this analysis shows association rather than direction, both MKKS-to-partner and partner-to-MKKS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of appetite by leptin-mediated signaling pathway grouped by MKKS-low versus MKKS-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MKKS→partner) and Y-score (partner→MKKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of appetite by leptin-mediated signaling pathway →	+0.173	+0.947	<.001	<.001	3	18
KIDNEY	Detection of mechanical stimulus involved in sensory perception of sound →	+1.177	+0.980	<.001	<.001	3	14
PANCREAS	Convergent extension →	+1.057	+0.996	<.001	<.001	2	12
SOFT_TISSUE	Regulation of cilium beat frequency involved in ciliary motility →	+0.164	+0.702	<.001	<.001	1	13
LUNG_NSCLC_LUAD	Leptin-mediated signaling pathway →	+0.118	+0.923	<.001	<.001	3	10
KIDNEY	Negative regulation of response to food →	+0.234	+0.894	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,354 associations by consensus.

Negative regulation of appetite by leptin-mediated signaling pathway by MKKS expression — KIDNEY

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