MKI67

Across TCGA patient cohorts, MKI67 mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKI67-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and Cyclin-E2. Each is linked with MKI67 in more than 5 cancer types. Because this analysis shows association rather than direction, both MKI67-to-partner and partner-to-MKI67 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MKI67-low versus MKI67-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKI67→partner) and Y-score (partner→MKI67) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+1.125	+2.321	<.001	.032	3	6
UCEC	ATM →	-0.415	-1.741	<.001	<.001	3	5
SKCM	Cyclin-E2 →	+0.126	+2.700	.016	.005	3	5
STAD	PI3K-p85 →	+0.150	+2.459	.040	.019	3	4
STAD	4E-BP1 →	+0.310	+3.169	.016	.018	3	4
SKCM	Caveolin-1 →	-0.551	-1.289	.005	.022	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

Caspase-7-cleavedD198 by MKI67 expression — STAD

Explore this box plot interactively →