MKI67

Across TCGA cell cohorts, MKI67 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,507 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MKI67-associated GO terms across cancer lineages are Nuclear chromosome segregation, Sister chromatid segregation, and Negative regulation of cell cycle process. Each is linked with MKI67 in more than 19 cancer types. Because this analysis shows association rather than direction, both MKI67-to-partner and partner-to-MKI67 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear chromosome segregation grouped by MKI67-low versus MKI67-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MKI67→partner) and Y-score (partner→MKI67) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nuclear chromosome segregation →	+0.102	+1.345	<.001	<.001	3	20
OESOPHAGUS	Sister chromatid segregation →	+0.123	+1.334	.001	<.001	3	20
BONE	Negative regulation of cell cycle process →	+0.099	+1.950	.001	.002	3	20
OESOPHAGUS	Mitotic nuclear division →	+0.169	+1.657	<.001	.001	3	20
BONE	Negative regulation of cell cycle phase transition →	+0.082	+1.687	.001	<.001	3	20
OESOPHAGUS	Positive regulation of chromosome condensation →	+0.285	+1.623	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,507 associations by consensus.

Nuclear chromosome segregation by MKI67 expression — BONE

Explore this box plot interactively →