MKI67

Across TCGA cell cohorts, MKI67 mutation is significantly associated with the mutation status of many other genes, with 5,922 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MKI67-associated genes across cancer lineages are DCHS1, CHD8, and SPHKAP. Each is linked with MKI67 in more than 8 cancer types. Because this analysis shows association rather than direction, both MKI67-to-partner and partner-to-MKI67 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCHS1 grouped by MKI67-low versus MKI67-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKI67→partner) and Y-score (partner→MKI67) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DCHS1 →	+2.364	+2.067	.001	.001	1	9
SOFT_TISSUE	CHD8 →	+5.066	+4.502	.007	.007	1	7
BONE	SPHKAP →	+5.000	+4.437	.007	.007	1	6
BONE	CTTNBP2 →	+5.000	+4.437	.007	.007	1	6
OVARY	ADCY5 →	+4.510	+3.047	.001	.001	1	6
SOFT_TISSUE	GLI2 →	+5.066	+4.502	.007	.007	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,922 associations by consensus.

DCHS1 by MKI67 expression — BLOOD_Leukemia

Explore this box plot interactively →