MISP3

Across TCGA patient cohorts, MISP3 protein abundance is significantly associated with the RNA expression of many other genes, with 10,021 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MISP3-associated genes across cancer lineages are SELENBP1, VSIG2, and TMPRSS2. Each is linked with MISP3 in more than 4 cancer types. Because this analysis shows association rather than direction, both MISP3-to-partner and partner-to-MISP3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MISP3 versus SELENBP1 in BRCA, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MISP3→partner) and Y-score (partner→MISP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SELENBP1 →	+1.305	+0.398	<.001	<.001	3	5
COAD	VSIG2 →	+2.158	+0.462	<.001	<.001	3	5
LUAD	TMPRSS2 →	+1.215	+0.480	<.001	.001	3	5
PDAC	RAD17P1 →	+1.321	+0.872	<.001	<.001	3	5
OV	COBL →	+1.168	+0.592	<.001	.002	2	5
UCEC	PEX11B →	+0.364	+0.358	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,021 associations by consensus.

MISP3 vs SELENBP1 — BRCA

Explore this scatter interactively →