MISP3

Across TCGA pan-cancer cohorts, MISP3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MISP3 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher MISP3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MISP3 expression acts as an unfavorable survival marker, although some lineages such as STAD and HNSC show a favorable association.

STAD, HNSC, and LGG are the cancer types where MISP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	All	0.745	0.550	<.001	122	view →
HNSC	OS	Tertile	All	0.831	0.718	.002	68	view →
LGG	DFS	Median	All	0.660	0.799	<.001	50	view →
UCS	DFS	Median	III,IV	0.214	0.609	<.001	50	view →
LIHC	DFS	Tertile	II,III,IV	0.213	0.476	.003	27	view →
LUAD	OS	Quartile	All	0.518	0.348	.001	21	view →
ESCA	OS	Median	All	0.577	1.000	.005	21	view →
UCEC	DFS	Median	III,IV	0.692	0.455	.015	18	view →
KIRP	DFS	Quartile	All	1.000	0.772	.013	14	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	12	view →
CHOL	DFS	Quartile	All	0.140	1.000	.002	11	view →
THCA	OS	Quartile	II,III,IV	0.899	0.333	.023	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MISP3–STAD (DFS)

Open the STAD breakdown →