MISP3

Across TCGA cell cohorts, MISP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,612 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MISP3-associated GO terms across cancer lineages are Negative regulation of transcription initiation-coupled chromatin remodeling, Cellular detoxification of aldehyde, and Fatty acid oxidation. Each is linked with MISP3 in more than 10 cancer types. Because this analysis shows association rather than direction, both MISP3-to-partner and partner-to-MISP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transcription initiation-coupled chromatin remodeling grouped by MISP3-low versus MISP3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MISP3→partner) and Y-score (partner→MISP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of transcription initiation-coupled chromatin remodeling →	+0.243	+1.895	<.001	<.001	3	11
KIDNEY	Cellular detoxification of aldehyde →	+0.134	+0.895	<.001	<.001	3	10
SKIN	Fatty acid oxidation →	+0.068	+0.591	<.001	.007	3	9
OVARY	Regulation of phospholipid biosynthetic process →	+0.134	+1.310	<.001	<.001	3	9
URINARY_TRACT	Monocarboxylic acid catabolic process →	+0.073	+1.053	.008	.007	3	9
STOMACH	Fatty acid catabolic process →	+0.074	+1.461	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,612 associations by consensus.

Negative regulation of transcription initiation-coupled chromatin remodeling by MISP3 expression — STOMACH

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