MISP

Across TCGA patient cohorts, MISP RNA expression is significantly associated with the protein abundance of many other proteins, with 10,207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MISP-associated proteins across cancer lineages are MISP_S543, MISP_S471, and MISP_S675. Each is linked with MISP in more than 8 cancer types. Because this analysis shows association rather than direction, both MISP-to-partner and partner-to-MISP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MISP versus MISP_S543 in BRCA, with a Pearson correlation of 0.72.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MISP→partner) and Y-score (partner→MISP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MISP_S543 →	+1.631	+2.542	<.001	<.001	3	9
OV	MISP_S471 →	+1.744	+1.341	.001	.002	2	8
BRCA	MISP_S675 →	+0.886	+2.266	<.001	<.001	3	7
UCEC	MISP_T377 →	+0.823	+1.574	<.001	<.001	3	7
BRCA	MISP_S348 →	+1.166	+1.902	<.001	<.001	3	6
PDAC	MISP_S575 →	+0.584	+0.950	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,207 associations by consensus.

MISP vs MISP_S543 — BRCA

Explore this scatter interactively →