MISP

Across TCGA patient cohorts, MISP protein abundance is significantly associated with the RNA expression of many other genes, with 12,101 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MISP-associated genes across cancer lineages are TSPAN1, BCAS1, and ARL14. Each is linked with MISP in more than 6 cancer types. Because this analysis shows association rather than direction, both MISP-to-partner and partner-to-MISP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MISP versus TSPAN1 in OV, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MISP→partner) and Y-score (partner→MISP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TSPAN1 →	+1.703	+0.511	<.001	<.001	3	7
GBM	BCAS1 →	+2.570	+0.946	<.001	.001	3	6
PDAC	ARL14 →	+1.069	+0.565	.001	<.001	3	5
UCEC	LINC00680 →	-0.631	-0.615	.008	.001	3	5
OV	ABHD11-AS1 →	+1.365	+0.531	<.001	<.001	3	5
OV	ZNF436-AS1 →	-0.712	-0.629	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,101 associations by consensus.

MISP vs TSPAN1 — OV

Explore this scatter interactively →