MISP

Across TCGA patient cohorts, MISP mutation is significantly associated with the RNA expression of many other genes, with 1,854 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MISP-associated genes across cancer lineages are ZNF483, ARHGEF10, and GLE1. Each is linked with MISP in more than 2 cancer types. Because this analysis shows association rather than direction, both MISP-to-partner and partner-to-MISP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF483 grouped by MISP-low versus MISP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MISP→partner) and Y-score (partner→MISP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ZNF483 →	+0.271	+2.593	<.001	.008	3	3
UCEC	ARHGEF10 →	+0.443	+1.914	.003	<.001	3	3
UCEC	GLE1 →	+0.412	+2.169	<.001	<.001	3	3
UCEC	PPP3CC →	+0.494	+1.914	<.001	<.001	3	3
UCEC	CDCA2 →	+0.770	+4.269	<.001	<.001	3	3
UCEC	MTCYBP14 →	+0.081	+1.633	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,854 associations by consensus.

ZNF483 by MISP expression — SKCM

Explore this box plot interactively →