MISP

Across TCGA patient cohorts, MISP mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MISP-associated genes across cancer lineages are FOXO3a_pS318_S321, Caspase-7-cleavedD198, and Rad50. Each is linked with MISP in more than 2 cancer types. Because this analysis shows association rather than direction, both MISP-to-partner and partner-to-MISP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by MISP-low versus MISP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MISP→partner) and Y-score (partner→MISP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.126	-2.212	.005	.010	3	3
UCEC	Caspase-7-cleavedD198 →	+0.745	+2.222	<.001	.009	3	3
UCEC	Rad50 →	-0.301	-3.446	<.001	.005	3	2
UCEC	STAT3_pY705 →	-0.381	-2.807	<.001	.002	3	2
UCEC	ATM →	-0.517	-2.446	.001	.018	3	2
SKCM	FoxM1 →	+0.175	+1.874	.038	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

FOXO3a_pS318_S321 by MISP expression — UCEC

Explore this box plot interactively →