MISP

Across TCGA cell cohorts, MISP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,817 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible MISP-associated GO terms across cancer lineages are Cell-cell adhesion mediated by cadherin, Regulation of action potential, and Protein localization to cell-cell junction. Each is linked with MISP in more than 10 cancer types. Because this analysis shows association rather than direction, both MISP-to-partner and partner-to-MISP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell-cell adhesion mediated by cadherin grouped by MISP-low versus MISP-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MISP→partner) and Y-score (partner→MISP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Cell-cell adhesion mediated by cadherin →	+0.207	+1.948	<.001	<.001	3	11
STOMACH	Regulation of action potential →	+0.156	+2.678	<.001	<.001	3	10
URINARY_TRACT	Protein localization to cell-cell junction →	+0.162	+2.659	.001	.002	3	10
PANCREAS	Bundle of His cell to Purkinje myocyte communication →	+0.286	+2.264	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Cellular response to molecule of fungal origin →	+1.634	+3.156	<.001	.001	3	9
OVARY	Regulation of potassium ion import →	+0.248	+2.981	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,817 associations by consensus.

Cell-cell adhesion mediated by cadherin by MISP expression — PANCREAS

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