MIS18A

Across TCGA pan-cancer cohorts, MIS18A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MIS18A data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MIS18A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MIS18A expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where MIS18A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.971	0.759	.002	29	view →
PDAC	DFS	Median	All	0.231	0.604	.018	16	view →
LUAD	DFS	Tertile	All	0.995	0.805	.019	5	view →
HNSC	DFS	Median	IV	0.771	0.538	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MIS18A–LSCC (OS)

Open the LSCC breakdown →