MIS18A

Across TCGA patient cohorts, MIS18A mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIS18A-associated genes across cancer lineages are ATM, HER3, and INPP4B. Each is linked with MIS18A in more than 1 cancer types. Because this analysis shows association rather than direction, both MIS18A-to-partner and partner-to-MIS18A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MIS18A-low versus MIS18A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIS18A→partner) and Y-score (partner→MIS18A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.548	-3.000	.036	.037	3	2
UCEC	HER3 →	-0.314	-2.986	.048	.037	3	1
UCEC	INPP4B →	-0.470	-2.986	.011	.037	1	2
UCEC	Caspase-7-cleavedD198 →	+0.878	+2.827	.010	.035	2	1
UCEC	eEF2 →	+0.417	+3.000	.044	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ATM by MIS18A expression — UCEC

Explore this box plot interactively →