MIS18A

Across TCGA cell cohorts, MIS18A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,623 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MIS18A-associated GO terms across cancer lineages are CENP-A containing chromatin assembly, Positive regulation of cell cycle process, and DNA replication. Each is linked with MIS18A in more than 18 cancer types. Because this analysis shows association rather than direction, both MIS18A-to-partner and partner-to-MIS18A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENP-A containing chromatin assembly grouped by MIS18A-low versus MIS18A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIS18A→partner) and Y-score (partner→MIS18A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CENP-A containing chromatin assembly →	+0.223	+1.170	.002	.002	3	19
SOFT_TISSUE	Positive regulation of cell cycle process →	+0.087	+0.708	<.001	<.001	3	18
BONE	DNA replication →	+0.139	+1.135	.002	.003	3	18
BLOOD_Myeloma	DNA replication initiation →	+0.167	+0.911	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.216	+0.963	.003	.002	3	18
SKIN	Kinetochore organization →	+0.164	+0.852	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,623 associations by consensus.

CENP-A containing chromatin assembly by MIS18A expression — BONE

Explore this box plot interactively →